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In some embodiments, the neurogenic sensitizing agent used with a muscarinic agent may be a reported inhibitor of an angiotensin converting enzyme (ACE). Non-limiting examples of such reported inhibitors include a sulfhydryl-containing (or mercapto-containing) agent, such as Alacepril, captopril (Capoten(Z), fentiapril, pivopril, pivalopril, or zofenopril; a dicarboxylate- containing agent, such as enalapril (Vasotec or Renitec ) or enalaprilat, ramipril (Altace(D or Tritace or Ramace ), quinapril (Accupril ) or quinapril hydrochloride, perindopril (Coversyl ) or perindopril erbumine (Aceon ), lisinopril (Lisodur or Prinivil or Zestril ); a phosphonate-containing (or phosphate-containing) agent, such as fosinopril (Monopril ), fosinoprilat, fosinopril sodium (CAS RN 88889-14-9), benazepril (Lotensin(b) or benazepril hydrochloride, imidapril or imidapril hydrochloride, moexipril (Univasc ), or trandolapril (Mavik ), yk11 quotes. In other embodiments, a modulator is administered in the form of an ester that increases biovavailability upon oral administration with subsequent conversion into metabolites with greater activity. Further embodiments include reported angiotensin II modulating entities that are naturally occurring, such as casokinins and lactokinins (breakdown products of casein and whey) which may be administered as such to obviate the need for their formation during digestion. The Meat of the Swai Is White and Flaky, yk11 quotes.
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